AWS Kiro Clinical Interoperability skill

Overview

The `clinical-interoperability` skill from AWS's Kiro for Life Sciences bundle. Its content is real and concretely on-standard: FHIR resource types (Patient, Observation, Condition, DiagnosticReport, MolecularSequence) including a documented pattern for mapping VCF fields into FHIR `Observation.component` elements per the FHIR Genomics Implementation Guide, HL7 v2 ORU/ADT/ORM message structure with a worked example encoding a BRCA1 pathogenic-variant result, and OMOP CDM guidance -- verified by direct fetch of the skill file itself. This entry is marked marginal, not clean, for a specific, disclosed reason: unlike the other skill entries seeded in this pass (which wrap an executable tool, API, or script with a defined input/output contract), this is a Kiro steering document (`inclusion: manual` frontmatter) -- reference guidance injected into an agent's context, with no script, API call, or defined return schema of its own. The `inputs`/`outputs` recorded below are this registry's own reasonable characterisation of a guidance-lookup skill, not a contract declared by the source. Terms check: the repository's root LICENSE.txt is MIT-0 (MIT No Attribution), confirmed by direct fetch; MIT-0 is not on this registry's SPDX allow-list (`schemas/vocab/licenses.json`), so this entry records `license: "other"` with `license_url` pointing at that LICENSE.txt rather than an approximate SPDX match, per this registry's own convention for a real but un-listed licence. The candidate research note that led to this check described '10 named domain skills plus 16 steering workflows' including a 'gene-disease-associations' workflow chaining ClinVar to OMIM to HPO; direct inspection confirmed both the count and this specific skill/steering-file split (`kiro-life-sciences/skills/` holds 10 domain-guidance files including this one, `kiro-life-sciences/steering/` holds 16 workflow files including `gene-disease-associations.md` and `fhir-clinical-integration.md`), and separately confirmed the repository also ships genuine MCP servers (e.g. `life-sciences-genomics`, wrapping NCBI/Ensembl/ClinVar/GEO/SRA) as a distinct component from these skill/steering files. No slug collision with any existing entry in this registry.

Details

Licence

other (full text)

Version

0.1.0

Category

Data curation

Homepage

https://github.com/aws-samples/sample-kiro-power-life-sciences/tree/main/kiro-life-sciences

Repository

https://github.com/aws-samples/sample-kiro-power-life-sciences

Maintainers

Susheel Varma (@susheel, GA4GH AI Workstream / Sage Bionetworks)

Keywords

fhirhl7v2omop-cdmclinical-interoperabilityaws-kirogenomics-in-fhir

Safety classification

No safety classification has been submitted for this entry.

Skill

Human oversight

recommended

Provenance logging

No

Evaluation criteria

https://github.com/aws-samples/sample-kiro-power-life-sciences/tree/main/kiro-life-sciences/tests

Source

https://github.com/aws-samples/sample-kiro-power-life-sciences.git (kiro-life-sciences/skills/clinical-interoperability.md)

Inputs

• data_exchange_scenario (string) — A description of the clinical or genomic data-exchange task, e.g. mapping a VCF variant into a FHIR Observation, parsing an HL7 v2 ORU message, or querying an OMOP CDM table. Not a declared API contract -- inferred by this registry from the guidance the skill provides.

Outputs

• interoperability_guidance (string) — Implementation guidance, resource/message/table mappings, and example payloads for the requested clinical-data-exchange standard. Not a declared return schema -- inferred by this registry from the guidance the skill provides.

Provenance

Created

2026-09-08T00:00:00.000Z

Updated

2026-09-08T00:00:00.000Z

Last verified

2026-09-08T00:00:00.000Z